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Search Results for " Nuclear factor-κB "

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阻害剤

146

天然化合物

リコンビナントタンパク質

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カタログ番号	製品名	別名	ターゲット
T3954	Adelmidrol		NF-κB , COX , PPAR
	Adelmidrol is an anti-inflammatory ethanolamide derivative of azelaic acid.		NF-κB , COX , PPAR
T16290	NIK SMI1		NF-κB
	NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits NIK-catalyzed hydrolysis of ATP to ADP (IC50: 0.23±0.17 nM).		NF-κB
TQ0305	CID-2858522		NF-κB
			NF-κB
T1930	JSH-23		NF-κB
	JSH-23, an NF-κB inhibitor（IC50= 7.1 μM）, suppresses the transcriptional activity.		NF-κB
T6661	SC75741		Influenza Virus , NF-κB
	SC75741 is a potent P65 inhibitor with IC50 of 200 nM		Influenza Virus , NF-κB
T16706	Quinoclamine		NF-κB
	Quinoclamine is a naphthoquinone derivative and is an NF-κB inhibitor.		NF-κB
T9917	Denosumab		RANKL/RANK
	Denosumab is a monoclonal antibody given subcutaneously that inhibits osteoclast activity by targeting the RANK ligand		RANKL/RANK
T8981	WAY-169916	WAY 169916,WAY169916	NF-κB
	WAY-169916 is a pathway-selective inhibitor of estrogen receptor (ER). It acts by inhibiting NF-kB transcriptional activity but being devoid of conventional estrogenic activity.		NF-κB
T10981	DCZ0415		Apoptosis , Others , NF-κB
	DCZ0415 induces antimyeloma activity in vitro, in vivo and in primary cells of drug-resistant myeloma patients. DCZ0415 is a potent TRIP13 inhibitor that can impair the repair of non-homologous end junctions and inhibit ...		Apoptosis , Others , NF-κB
T13604	CDDO-dhTFEA		Others , NF-κB , Nrf2
	CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor. It restores mean arterial pressure (MAP), elevates Nrf2 levels and the expressi...		Others , NF-κB , Nrf2
T6204	QNZ	CAY10470,EVP4593	TNF , NF-κB
	QNZ (EVP4593) (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively.		TNF , NF-κB
T22115	SM-7368		NF-κB
	The NF-κB Activation Inhibitor III, controls the biological activity of NF-κB. It is primarily used for Inflammation/Immunology applications.		NF-κB
T6454	CORM-3	CORM3	Others , NF-κB , NOD-like Receptor (NLR)
	CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.		Others , NF-κB , NOD-like Receptor (NLR)
T8550	NDMC101		Others , NF-κB , Proteasome
	NDMC101 is an inhibitor of dipeptidyl peptidase-IV activity in human T cells and exhibits immunomodulatory effects. It also acts as a novel inhibitor of NFATc1 and NF-κB activity.		Others , NF-κB , Proteasome
T19853	Dimethoxycurcumin	Veratrylcurcuminoid	Others
	Dimethoxycurcumin (Veratrylcurcuminoid) is an analog of curcumin with more metabolical stability. Dimethoxycurcumin induces epigenetic changes in leukemia cells and the expression of promoter methylated genes.		Others
T1934	Bay 11-7085	BAY 11-7083	Apoptosis , IκB/IKK , Ferroptosis , NF-κB
	Bay 11-7085 can irreversibly inhibit the IκBα phosphorylation induced by TNFα (IC50: 10 μM).		Apoptosis , IκB/IKK , Ferroptosis , NF-κB
TD0099	Malachite green oxalate		Apoptosis , Others , IκB/IKK , NF-κB
	Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions.		Apoptosis , Others , IκB/IKK , NF-κB
T39924	NF-κΒ activator 2		NF-κB
	NF-κΒ Activator 2 is a potent, orally active compound that efficiently activates NF-κB with an EC50 value of 1.58 μM. By enhancing NF-κB expression and activation, it induces SOD 2 synthesis, rendering it useful for amyo...		NF-κB
T6027	Delanzomib	CEP-18770	Apoptosis , NF-κB , Proteasome
	Delanzomib (CEP-18770) is an orally active inhibitor of the chymotrypsin-like activity of proteasome (IC50: 3.8 nM). It only marginally inhibits the tryptic and peptidylglutamyl activities of the proteosome.		Apoptosis , NF-κB , Proteasome
T7511	Cyclo(his-pro)		NF-κB , Endogenous Metabolite
	Cyclo(his-pro) is an endogenous cyclic dipeptide that exerts oxidative damage protection by selectively activating the transcription factor Nrf2 signalling pathway.		NF-κB , Endogenous Metabolite
T0907	Sulfasalazine	NSC 667219,Azulfidine	Apoptosis , Ferroptosis , NF-κB , COX , Antibacterial , Antibiotic , Autophagy
	Sulfasalazine (Azulfidine) is a synthetic salicylic acid derivative with affinity for connective tissues containing elastin and formulated as a prodrug
T1229	Erdosteine	RV 144,KW-9144	NF-κB , Antibacterial , Adenosine deaminase
	Erdosteine (RV 144) is a homocysteine-derived thiol derivative with mucolytic and free radical scavenging properties. Erdosteine and its metabolites modulate mucus production and viscosity, by which facilitating mucocili...		NF-κB , Antibacterial , Adenosine deaminase
T8799	(E/Z)-IT-603	IT603	Others , NF-κB
	(E/Z)-IT-603 is a cell-permeable c-Rel inhibitor (IC50: 3μM). IT-603 directly and reversibly binds to c-Rel to change its conformation and blocks its DNA binding and transcriptional activity.		Others , NF-κB
T4564	Ethacrynic acid	Edecrin,Etacrynic Acid,Hydromedin	Others , Calcium Channel , NF-κB , GST
	Ethacrynic acid (Edecrin) is a nonsulfonamide loop diuretic that inhibits the activity of the Na+/K+/2Cl- cotransporter NKCC2 in the thick ascending limb of the loop of Henle. It also inhibits glutathione S-transferase a...		Others , Calcium Channel , NF-κB , GST
T1144L	Lidocaine Hydrochloride hydrate		EGFR , Sodium Channel
	Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.		EGFR , Sodium Channel
T6941	PI-1840	PI 1840	PARP , Proteasome
	PI-1840（IC50 = 27 nM）is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and postglutamyl-peptide-hydrolysis-like (PGPH-L).		PARP , Proteasome
T0708	Oxaprozin	Oxaprozinum,Wy21743	NF-κB , COX
	Oxaprozin (Oxaprozinum) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of oxaprozin is as a Cyclooxygenase Inhibitor. The chemical classification of oxaprozin is Nonsteroidal Anti-inflammatory Compound...		NF-κB , COX
T17217	Vamorolone	VBP15	Glucocorticoid Receptor , NF-κB
	Vamorolone (VBP15) is an orally active dissociative steroidal anti-inflammatory drug and membrane-stabilizer. Vamorolone improves muscular dystrophy without side effects. Vamorolone displays effective NF-κB inhibition an...		Glucocorticoid Receptor , NF-κB
T0468	Lidocaine	Lignocaine,Alphacaine,Xylocaine	Apoptosis , ERK , NF-κB , MEK , Sodium Channel , Histamine Receptor
	Lidocaine (Alphacaine) is an amide local anesthetic with anti-inflammatory properties in vitro and in vivo. It has this functions perhaps due to an attenuation of intracellular adhesion molecule-1 (ICAM-1), pro-inflammat...
T6561	Laquinimod	LAQ,ABR-215062	Apoptosis , Others , NF-κB
	Laquinimod (LAQ) is an effective immunomodulator, which is currently under development in phase III trials for the treatment of multiple sclerosis as an oral therapy.		Apoptosis , Others , NF-κB
T16974	TAK-243	MLN7243	Apoptosis , E1/E2/E3 Enzyme , NF-κB
	TAK-243 (MLN7243) is a selective inhibitor of the ubiquitin-activating enzyme UAE (IC50=1 nM). TAK-243 blocks ubiquitin binding and disrupts mono-ubiquitin signaling as well as overall protein ubiquitination. TAK-243 exh...		Apoptosis , E1/E2/E3 Enzyme , NF-κB
T0304	Methylthiouracil	NSC-193526,NSC-9378,MTU	ERK , Antiviral , TNF , NF-κB , Interleukin
	Methylthiouracil (NSC-193526) is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.		ERK , Antiviral , TNF , NF-κB , Interleukin
T2131	Articaine hydrochloride	Ultracaine,Articaine HCl,Hoe-045	Sodium Channel
	Articaine hydrochloride (Hoe-045) is a thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE.		Sodium Channel
T9010	IMM-H007		Others , AMPK
	IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression		Others , AMPK
T6495	EUK-134	EUK 134	Beta Amyloid
	EUK-134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.		Beta Amyloid
T0005	Aspirin	Acetylsalicylate,Acetylsalicylic Acid,ASA	Mitophagy , Virus Protease , COX , Autophagy
	Aspirin (Acetylsalicylic Acid) is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Aspirin is a histone deacetylase inhibitors to up-regulate cel...		Mitophagy , Virus Protease , COX , Autophagy
T1144	Lidocaine hydrochloride	Lidocaine HCL,Lignocaine hydrochloride,Xyloneural,Lidothesin	Apoptosis , ERK , NF-κB , MEK , Sodium Channel
	Lidocaine hydrochloride (Lignocaine hydrochloride) is a local anesthetic and cardiac depressant used as an antiarrhythmic agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its ...		Apoptosis , ERK , NF-κB , MEK , Sodium Channel
T6823	E3330		HIF/HIF Prolyl-Hydroxylase , DNA/RNA Synthesis
	E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.		HIF/HIF Prolyl-Hydroxylase , DNA/RNA Synthesis
T25465	GS143	GS-143,GS 143	IκB/IKK , E1/E2/E3 Enzyme , NF-κB
	GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 suppresses NF-κB activation and transcription of target genes and does not inhibit protea...		IκB/IKK , E1/E2/E3 Enzyme , NF-κB
T0459	Sulindac	Arthrocine,MK-231,Clinoril,Sulindac sulfoxide	COX , Autophagy
	Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cycl...		COX , Autophagy
T3147	Pyrrolidinedithiocarbamate ammonium	PDTC,Pyrrolidinedithiocarbamate,APDC,1-Pyrrolidinedithiocarboxylic acid ammonium salt,Ammonium pyrrolidinedithiocarbamate	NF-κB
	Pyrrolidinedithiocarbamate ammonium (1-Pyrrolidinedithiocarboxylic acid ammonium salt), a selective NF-κB inhibitor, inhibits translation of nitric oxide synthase mRNA to prevent induction.		NF-κB
T2399	Bortezomib	Radiciol,NSC 681239,MG 341,DPBA,Brotezamide,LDP 341	Apoptosis , NF-κB , Proteasome , Autophagy
	Bortezomib (LDP 341) is a 20S proteasome inhibitor (Ki=0.6 nM) that is reversible and selective. Bortezomib has antitumor activity and inhibits NF-κB, which can disrupt the cell cycle and induce apoptosis.		Apoptosis , NF-κB , Proteasome , Autophagy
T4361	CBL0137 hydrochloride	CBL0137,CBLC137,Curaxin 137,CBL-C137 hydrochloride,Curaxin-137 hydrochloride	Others , NF-κB , p53
	CBL0137 hydrochloride (Curaxin-137 hydrochloride) activates p53 and inhibits NF-kB (EC50: 0.37/0.47 μM) in the cell-based p53 and NF-kB reporter assays, respectively. It also suppresses histone chaperone FACT.		Others , NF-κB , p53
T6690	T0901317		Apoptosis , FXR , Liver X Receptor , ROR
	T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).		Apoptosis , FXR , Liver X Receptor , ROR
T25888	NSC-670224	NSC 670224
	NSC-670224 is an inhibitor of histone deacetylases-6 (HDAC6) and nuclear factor-κB (NF-κB) activation blocker. It has been shown to be toxic to Saccharomyces cerevisiae at low micromolar concentrations, potentially acts ...
T80618	Narlumosbart		RANKL/RANK
	Narlumosbart (JMT103) is an IgG4κ monoclonal antibody that selectively binds to the receptor activator of nuclear factor-κB ligand (RANKL)[1].		RANKL/RANK
T27192	DMI-9523	DA-DKP,Ampion,DMI 9523,DM-9523
	DMI-9523 is nuclear factor NF-κB activation inhibitor. Antigen-stimulated human T lymphocytes produce significantly lower quantities of interferon-gamma and tumor necrosis factor-alpha after stimulation in vitro in the p...
T73061	Amakusamine
	Amakusamine effectively suppresses the formation of multinuclear osteocasts triggered by the receptor activator of nuclear factor-κB ligand (RANKL) with an inhibitory concentration (IC50) of 10.5 μM in RAW264.7 cells.
T27033	CKD-712	CKD 712,CKD712
	CKD-712 is a nuclear factor NF-kappa B inhibitor. CKD-712 suppressed MMP-9, but not MMP-2 and other NF-κB-regulated proteins involved in cancer metastasis such as VEGF. CKD-712 induced cell cycle arrest at G2M phase by s...
T35986	CAY10512
	The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inh...

Compounds

Adelmidrol

T3954

Synonym:

Target: NF-κB, COX, PPAR

Target: Influenza Virus, NF-κB

Synonym: WAY 169916,WAY169916

Target: Apoptosis, Others, NF-κB

CDDO-dhTFEA

T13604

Synonym:

Target: Others, NF-κB, Nrf2

QNZ

T6204

Synonym: CAY10470,EVP4593

Target: Others, NF-κB, NOD-like Receptor (NLR)

NDMC101

T8550

Synonym:

Target: Others, NF-κB, Proteasome

Dimethoxycurcumin

T19853

Synonym: Veratrylcurcuminoid

Target: Apoptosis, IκB/IKK, Ferroptosis, NF-κB

Malachite green oxalate

TD0099

Synonym:

Target: Apoptosis, Others, IκB/IKK, NF-κB

Target: Apoptosis, NF-κB, Proteasome

Cyclo(his-pro)

T7511

Synonym:

Target: NF-κB, Endogenous Metabolite

Sulfasalazine

T0907

Synonym: NSC 667219,Azulfidine

Target: Apoptosis, Ferroptosis, NF-κB, COX, Antibacterial, Antibiotic, Autophagy

Erdosteine

T1229

Synonym: RV 144,KW-9144

Target: NF-κB, Antibacterial, Adenosine deaminase

(E/Z)-IT-603

T8799

Synonym: IT603

Target: Others, NF-κB

Ethacrynic acid

T4564

Synonym: Edecrin,Etacrynic Acid,Hydromedin

Target: Others, Calcium Channel, NF-κB, GST

Lidocaine Hydrochloride hydrate

T1144L

Synonym:

Target: EGFR, Sodium Channel

PI-1840

T6941

Synonym: PI 1840

Target: PARP, Proteasome

Oxaprozin

T0708

Synonym: Oxaprozinum,Wy21743

Target: Glucocorticoid Receptor, NF-κB

Lidocaine

T0468

Synonym: Lignocaine,Alphacaine,Xylocaine

Target: Apoptosis, ERK, NF-κB, MEK, Sodium Channel, Histamine Receptor

Laquinimod

T6561

Synonym: LAQ,ABR-215062

Target: Apoptosis, Others, NF-κB

TAK-243

T16974

Synonym: MLN7243

Target: Apoptosis, E1/E2/E3 Enzyme, NF-κB

Methylthiouracil

T0304

Synonym: NSC-193526,NSC-9378,MTU

Target: ERK, Antiviral, TNF, NF-κB, Interleukin

Articaine hydrochloride

T2131

Synonym: Ultracaine,Articaine HCl,Hoe-045

Target: Sodium Channel

Synonym: Acetylsalicylate,Acetylsalicylic Acid,ASA

Target: Mitophagy, Virus Protease, COX, Autophagy

Lidocaine hydrochloride

T1144

Synonym: Lidocaine HCL,Lignocaine hydrochloride,Xyloneural,Lidothesin

Target: Apoptosis, ERK, NF-κB, MEK, Sodium Channel

E3330

T6823

Synonym:

Target: HIF/HIF Prolyl-Hydroxylase, DNA/RNA Synthesis

GS143

T25465

Synonym: GS-143,GS 143

Target: IκB/IKK, E1/E2/E3 Enzyme, NF-κB

Sulindac

T0459

Synonym: Arthrocine,MK-231,Clinoril,Sulindac sulfoxide

Target: COX, Autophagy

Pyrrolidinedithiocarbamate ammonium

T3147

Synonym: PDTC,Pyrrolidinedithiocarbamate,APDC,1-Pyrrolidinedithiocarboxylic acid ammonium salt,Ammonium pyrrolidinedithiocarbamate

Target: NF-κB

Bortezomib

T2399

Synonym: Radiciol,NSC 681239,MG 341,DPBA,Brotezamide,LDP 341

Target: Apoptosis, NF-κB, Proteasome, Autophagy

CBL0137 hydrochloride

T4361

Synonym: CBL0137,CBLC137,Curaxin 137,CBL-C137 hydrochloride,Curaxin-137 hydrochloride

Target: Others, NF-κB, p53

T0901317

T6690

Synonym:

Target: Apoptosis, FXR, Liver X Receptor, ROR

Synonym: DA-DKP,Ampion,DMI 9523,DM-9523

Synonym: CKD 712,CKD712

カタログ番号	製品名	別名	ターゲット
T10383	Asatone		NF-κB
	Asatone, an active component isolated from Radix et Rhizoma Asari, has an anti-inflammatory effect via activation of NF-κB and downregulation of p-MAPK (ERK, JNK, and p38) pathways.		NF-κB
TN1131	Handelin		NF-κB , Immunology/Inflammation related
	Handelin has anti-inflammatory activity by inhibiting NF-κB activation and pro-inflammatory cytokine productions.		NF-κB , Immunology/Inflammation related
T5688	Micheliolide		NOS , NF-κB , COX
	Micheliolide(MCL) is a sesquiterpene lactone which inhibits various inflammatory response.		NOS , NF-κB , COX
T4S1540	Myrislignan		Apoptosis , NF-κB
	Myrislignan has anti-inflammatory, and anti-cancer activities, it inhibited NF-κB signalling pathway activation, inhibited the proliferation of A549 cells in a dose- and time-dependent manner, it also significantly induc...		Apoptosis , NF-κB
T3S1641	Esculentoside H		TNF , NF-κB , JNK
	Phytolaccaceae has anti-tumor activity, the mechanism may be related to the capacity of Esculentoside H for TNF release.		TNF , NF-κB , JNK
T13686	Ergolide		NF-κB
	Ergolide, a sesquiterpene lactone extracted from the dried flowers of Inula Britannica, effectively hinders the expression of inducible nitric oxide synthase and cyclo-oxygenase-2 in RAW 264.7 macrophages by deactivating...		NF-κB
T4S0217	HOMOPLANTAGININ		TNF , NF-κB
	Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia,it has a protective and therapeutic effect on hepatocyte injury and shows potent inhibitory activities against influenza.		TNF , NF-κB
T6S0119	Dauricine		Apoptosis , Others , NF-κB
	1. Dauricine has pulmonary toxicity, can produce pulmonary injury in CD-1 mice by the metabolism of Dauricine mediated by CYP3A. 2. Dauricinec can pass the blood-brain barrier, and that P-glycoprotein has an important ro...		Apoptosis , Others , NF-κB
T3S0807	Berbamine		CaMK , NF-κB , Autophagy
	Berbamine is a natural product extracted from Phellodendron amurense. It acts as a calcium channel blocker and possesses anti-tumor, immunomodulatory, and cardiovascular effects.		CaMK , NF-κB , Autophagy
T3251	Stachydrine Hydrochloride		NF-κB
	Stachydrine Hydrochloride is an effective component that mainly extracted from the leaf of Leonurussibiricus.		NF-κB
T5S2129	Sciadopitysin		TNF , NF-κB
	Sciadopitysin may prevent the development of diabetic osteopathy, it exerts its therapeutic effects via upregulation of mitochondrial biogenesis.Sciadopitysin shows protective effects on antimycin A-induced toxicity in o...		TNF , NF-κB
TMA0507	Tomatidine		NF-κB , JNK , Autophagy
	Tomatidine serves as an anti-inflammatory agent by inhibiting NF-κB and JNK signaling pathways. Additionally, it induces autophagy in both mammalian cells and C. elegans.		NF-κB , JNK , Autophagy
TN2008	Okanin		NF-κB , TLR
	Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect.		NF-κB , TLR
T3913	Saikosaponin D		Estrogen Receptor/ERR , NF-κB , Antibacterial , STAT
	Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.		Estrogen Receptor/ERR , NF-κB , Antibacterial , STAT
T3S1707	Dendrophenol	Moscatilin	NF-κB
	Dendrophenol (Moscatilin) is a natural product isolated from the stem of Dendrobium loddigesii Rolfe, act as a NF-κB inhibitor. Antineoplastic activity.		NF-κB
T5795	Suberosin		Others , NF-κB
	Suberosin exhibits anti-inflammatory, and anticoagulant activities, it also shows biting deterrent activity against Aedes aegypti, it may be useful for use as mosquito larvicidal agent.		Others , NF-κB
T16324	Nimbolide		Apoptosis , NF-κB , CDK
	Nimbolide suppresses CDK4/CDK6 kinase activity. Nimbolide inhibits the NF-κB, Wnt, PI3K-Akt, MAPK, and JAK-STAT signaling pathways. Nimbolide causes apoptosis through the inactivation of NF-κB. Nimbolide is a triterpene ...		Apoptosis , NF-κB , CDK
T3877	Esculentoside A		NF-κB , COX
	Esculentoside A can suppress inflammatory responses in LPS-induced ALI through inhibition of the NF-κB and mitogen-activated protein kinase signaling pathways. Esculentoside A may be useful for the treatment of autoimmun...		NF-κB , COX
T11060	DMAPT	Dimethylamino Parthenolide	NF-κB
	DMAPT (Dimethylamino Parthenolide) is a water-soluble analogue of Parthenolide (PTL). It is an orally active NF-κB inhibitor with an LD50 of 1.7 μM on primary acute myeloid leukemia cells.		NF-κB
T4S0800	Demethyleneberberine		P450 , NOS , NF-κB , HIF , AMPK
	Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either in vitro or in vivo.Demethyleneberberine suppresses CYP2E1,...		P450 , NOS , NF-κB , HIF , AMPK
T4S1881	Aconine	Jesaconine	Others , NF-κB
	1. Aconine (Jesaconine) is the febrifuge. 2. Aconine possesses gastric anaesthetic props.		Others , NF-κB
T6718	Zingerone	Gingerone,Vanillylacetone,NSC 15335	NF-κB
	Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antidiarrhoeic, antilipolytic, antispasmodic and anti-tumor properties. Zingerone(Gi...		NF-κB
TN1079	Deoxyelephantopin		NF-κB
	Deoxyelephantopin has anti-inflammatory, hepatoprotective, and wound healing activities; it also has antitumor activity.Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling		NF-κB
TN1712	Gossypin		NF-κB , S6 Kinase
	Gossypin has antidiabetic, antioxdiant, anticonvulsant, anti-allergic, antiinflammatory, antinociceptive, cytotoxic and antibacterial activities; it inhibits the NF-kappaB activation pathway, which may explain its role i...		NF-κB , S6 Kinase
T3777	Praeruptorin A	(+)-Praeruptorin A	CaMK , NF-κB
	Praeruptorin A ((+)-Praeruptorin A) has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulin and inhibiting the Ca(2+)/calmodulin-CaMKIV-CREB-NFATc1 and/or...		CaMK , NF-κB
T6S0840	Engeletin	Dihydrokaempferol 3-rhamnoside	NF-κB , Reductase
	1. Engeletin (Dihydrokaempferol 3-rhamnoside) may serve as a potential anti-inflammatory agent. 2. Engeletin possesses potent inhibition of PGE2 release with IC5 values of 19.6 μg/ml. 3. Engeletin inhibits a recombinant ...		NF-κB , Reductase
T5S1607	Morusin	Mulberrochromene	NF-κB , Antibacterial , STAT
	1. Morusin (Mulberrochromene) possesses antitumor effects of cell lines including HT-29, A549, MCF-7, and MDA-MB-231, through suppressing STAT3 and NFκB attenuation mediated apoptosis induction. 2. Morusin possesses anti...		NF-κB , Antibacterial , STAT
T5834	Myrcene		Others
	Myrcene is a terpene that has been found in Cannabis and has antioxidative properties.		Others
T2726	Sinomenine	Cucoline,Kukoline	Apoptosis , Others , NF-κB , Opioid Receptor , Autophagy
	Sinomenine (Kukoline) is a pure alkaloid isolated from the Sinomenium acutum, is utilized in the treatment of rheumatism and arthritis.		Apoptosis , Others , NF-κB , Opioid Receptor , Autophagy
T4518	Licochalcone D		ERK , NF-κB
	Licochalcone D may be a potential drug for human melanoma treatment by inhibiting proliferation, inducing apoptosis via the mitochondrial pathway and blocking cell migration and invasion. Licochalcone D has cardioprotect...		ERK , NF-κB
T6S1572	Sauchinone		ERK , p38 MAPK , NF-κB
	1. Sauchinone is a useful adjunctive treatment for bacterial infection. 2. Sauchinone, an active lignan found in Saururus chinensis, to regulate the activation of HSCs, to prevent liver fibrosis, and to inhibit oxidative...		ERK , p38 MAPK , NF-κB
T6S0781	Phellodendrine	Phallodendrin	Others , NF-κB , Akt
	1. Phellodendrine (Phallodendrin) has anti-nephritic activity, may be due to its ability to inhibit the proliferation or the migration of macrophages and cytotoxic T lymphocytes in the glomeruli.		Others , NF-κB , Akt
T2140	Parthenolide	(-)-Parthenolide	Apoptosis , Mitophagy , NF-κB , HDAC , Autophagy
	(-)-Parthenolide ((-)-Parthenolide), an inhibitor of the Nuclear Factor-κB Pathway, also promotes the ubiquitination of MDM2 and activates p53 cellular functions.		Apoptosis , Mitophagy , NF-κB , HDAC , Autophagy
T3012	Mangiferin	Alpizarin,Chinomin,Hedysarid	Apoptosis , Others , NF-κB , Nrf2
	Mangiferin (Hedysarid) is used for antidiabetes. Extracted from Mangifera indica L.		Apoptosis , Others , NF-κB , Nrf2
TN1341	8-Deoxygartanin		Beta Amyloid , NF-κB , Parasite
	8-Deoxygartanin is a butyrylcholinesterase (BChE) selective inhibitor, it exhibits significant inhibition of self-induced α2-amyloid (Aα2) aggregation, it has multifunctional activities against Alzheimer's disease (AD) a...		Beta Amyloid , NF-κB , Parasite
T6S0659	Rhynchophylline	Rhynchophyllin,Rhyncophylline,Mitrinermine,Mitrinermin	Calcium Channel , NF-κB
	1. Rhynchophylline (Mitrinermine) can protect against ischemic damage, probably via regulating the Akt/mTOR pathway. 2. Rhynchophylline can protect against glutamate-induced neuronal death, can inhibit MA impairment in c...		Calcium Channel , NF-κB
T2920	Berbamine dihydrochloride	Berbamine,dihydrochloride	Apoptosis , NF-κB , Bcr-Abl , Autophagy
	Berbamine dihydrochloride (Berbamine), a natural compound derived from the Berberis amurensis plant, has been shown to exhibit antitumor activity in several Ys.		Apoptosis , NF-κB , Bcr-Abl , Autophagy
T2898	Andrographolide	Andrographis	SARS-CoV , Influenza Virus , NF-κB , Autophagy
	Andrographolide (Andrographis)(Andrographis), an irreversible antagonist of NF-κB, has anti-inflammatory and anti-platelet aggregation activities and potential antineoplastic.		SARS-CoV , Influenza Virus , NF-κB , Autophagy
TN2244	Sulfuretin		NF-κB , Autophagy
	Sulfuretin is a potent anti-oxidant, has protective effect against t-BHP-induced oxidative damage in human liver-derived HepG2 cells is attributable to its ability to scavenge ROS and up-regulate the activity of HO-1 thr...		NF-κB , Autophagy
T3893	Forsythoside B		TNF , NF-κB
	Forsythoside B binds to LPS and reduces the biological activity of serum LPS, and inhibits NF-κB activation. Forsythoside B inhibits the inflammatory response and has antioxidant properties. Potent neuroprotective effect...		TNF , NF-κB
T5687	WITHAFERIN A		Ferroptosis , NF-κB
	WITHAFERIN A is a novel class of NFkappaB inhibitors, which hold promise as novel anti-inflammatory agents for treatment of various inflammatory disorders and/or cancer.		Ferroptosis , NF-κB
TN1637	Eurycomalactone		Anti-infection , NF-κB
	Eurycomalactone is a natural product isolated from Eurycoma longifolia Jack., acts as a potent NF-κB inhibitor( IC50 of 0.5 μM). Eurycomalactone inhibits protein synthesis, depletes cyclin D1, but does not affect TNFα-in...		Anti-infection , NF-κB
T6S1966	Curculigoside	Curculigoside A	Antioxidant , NF-κB , JAK , STAT
	1. Curculigoside (Curculigoside A) can prevent bone loss , improve osteogenesis and inhibit osteoclastogenesis of hAFSCs, suggesting its potential use to regulate hAFSC osteogenic differentiation for treating bone disord...		Antioxidant , NF-κB , JAK , STAT
T2733	Sarsasapogenin	Parigenin,Sarsagenin	Apoptosis , NF-κB , Endogenous Metabolite
	Sarsasapogenin (Parigenin) is a steroidal sapogenin, that is the aglycosidic portion of a plant saponin. It is named after sarsaparilla (Smilax sp.), a family of climbing plants found in subtropical regions. It was one o...		Apoptosis , NF-κB , Endogenous Metabolite
TL0016	Sulforaphene		Apoptosis , ERK , EGFR , NF-κB
	Sulforaphene is a natural product isolated from radish seeds, exhibits an ED50 against velvetleaf seedlings approximately 2 x 10 -4 M. Sulforaphene promotes cancer cells apoptosis and inhibits migration via inhibiting EG...		Apoptosis , ERK , EGFR , NF-κB
T5S1891	Flaconitine	3-Acetylaconitine,Acetylaconitine	Others , NF-κB
	Flaconitine (Acetylaconitine) is an NF-κB inhibitor and an alkaloid.		Others , NF-κB
T3860	Isoliquiritin apioside		MMP , p38 MAPK , NF-κB
	Isoliquiritin apioside, isolated from Glycyrrhizae radix rhizome, significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresse...		MMP , p38 MAPK , NF-κB
TN1721	Gypenoside L		ERK , p38 MAPK , Calcium Channel , NF-κB , ROS
	Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. It also inhibit non-small cell lung carcinoma A549 cell inhibitory a...		ERK , p38 MAPK , Calcium Channel , NF-κB , ROS
T6S1543	Dehydrodiisoeugenol		Others , NF-κB , COX , Antibacterial
	1. Dehydrodiisoeugenol has anti-inflammatory activity. (1). Dehydrodiisoeugenol inhibited the expression of the COX-2 in RAW264.7 murine macrophages stimulated with LPS. (2). Dehydrodiisoeugenol inhibited LPS-stimulated ...		Others , NF-κB , COX , Antibacterial
T3S0738	Yangonin	Y100550	Cannabinoid Receptor , NF-κB , Autophagy
	Yangonin (Y100550) is a novel CB receptor ligand, it exhibits affinity for the human recombinant CB receptor. Yangonin (Y100550) could be a valuable candidate for the intervention of NF-κB-dependent pathological conditio...		Cannabinoid Receptor , NF-κB , Autophagy
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天然物製品

Target: NF-κB, Immunology/Inflammation related

Micheliolide

T5688

Synonym:

Target: NOS, NF-κB, COX

Myrislignan

T4S1540

Synonym:

Target: Apoptosis, NF-κB

Esculentoside H

T3S1641

Synonym:

Target: TNF, NF-κB, JNK

Target: Apoptosis, Others, NF-κB

Berbamine

T3S0807

Synonym:

Target: CaMK, NF-κB, Autophagy

Stachydrine Hydrochloride

Target: NF-κB, JNK, Autophagy

Target: Estrogen Receptor/ERR, NF-κB, Antibacterial, STAT

Target: Others, NF-κB

Nimbolide

T16324

Synonym:

Target: Apoptosis, NF-κB, CDK

Synonym: Dimethylamino Parthenolide

Target: P450, NOS, NF-κB, HIF, AMPK

Aconine

T4S1881

Synonym: Jesaconine

Target: Others, NF-κB

Zingerone

T6718

Synonym: Gingerone,Vanillylacetone,NSC 15335

Target: NF-κB, S6 Kinase

Praeruptorin A

T3777

Synonym: (+)-Praeruptorin A

Target: CaMK, NF-κB

Engeletin

T6S0840

Synonym: Dihydrokaempferol 3-rhamnoside

Target: NF-κB, Reductase

Morusin

T5S1607

Synonym: Mulberrochromene

Target: NF-κB, Antibacterial, STAT

Synonym: Cucoline,Kukoline

Target: Apoptosis, Others, NF-κB, Opioid Receptor, Autophagy

Target: ERK, p38 MAPK, NF-κB

Phellodendrine

T6S0781

Synonym: Phallodendrin

Target: Others, NF-κB, Akt

Parthenolide

T2140

Synonym: (-)-Parthenolide

Target: Apoptosis, Mitophagy, NF-κB, HDAC, Autophagy

Mangiferin

T3012

Synonym: Alpizarin,Chinomin,Hedysarid

Target: Apoptosis, Others, NF-κB, Nrf2

8-Deoxygartanin

TN1341

Synonym:

Target: Beta Amyloid, NF-κB, Parasite

Rhynchophylline

T6S0659

Synonym: Rhynchophyllin,Rhyncophylline,Mitrinermine,Mitrinermin

Target: Calcium Channel, NF-κB

Berbamine dihydrochloride

T2920

Synonym: Berbamine,dihydrochloride

Target: Apoptosis, NF-κB, Bcr-Abl, Autophagy

Andrographolide

T2898

Synonym: Andrographis

Target: SARS-CoV, Influenza Virus, NF-κB, Autophagy

Sulfuretin

TN2244

Synonym:

Target: NF-κB, Autophagy

Target: Ferroptosis, NF-κB

Eurycomalactone

TN1637

Synonym:

Target: Anti-infection, NF-κB

Curculigoside

T6S1966

Synonym: Curculigoside A

Target: Antioxidant, NF-κB, JAK, STAT

Sarsasapogenin

T2733

Synonym: Parigenin,Sarsagenin

Target: Apoptosis, NF-κB, Endogenous Metabolite

Sulforaphene

TL0016

Synonym:

Target: Apoptosis, ERK, EGFR, NF-κB

Flaconitine

T5S1891

Synonym: 3-Acetylaconitine,Acetylaconitine

Target: Others, NF-κB

Isoliquiritin apioside

T3860

Synonym:

Target: MMP, p38 MAPK, NF-κB

Gypenoside L

TN1721

Synonym:

Target: ERK, p38 MAPK, Calcium Channel, NF-κB, ROS

Dehydrodiisoeugenol

T6S1543

Synonym:

Target: Others, NF-κB, COX, Antibacterial

yangonin

T3S0738

Synonym: Y100550

Target: Cannabinoid Receptor, NF-κB, Autophagy

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Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPJ-00662	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli)	Human	E. coli
	CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL i...
TMPJ-01466	Osteoprotegerin Protein, Human, Recombinant (aa 22-401, His)	Human	Human Cells
	TNFRSF11B is a secreted protein, containing 2 death domains and 4 TNFR-Cys repeats. TNFRSF11B is a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL). By binding RANKL, TNFRSF11B inhibits ...
TMPJ-00850	ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His)	Mouse	Human Cells
	ST2, also called IL-1 R4, is an Interleukin-1 receptor family glycoprotein that plays a role in Th2 immune responses. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiac myocytes....
TMPJ-00849	ST2/IL-1 RL1 Protein, Mouse, Recombinant (V192A, hFc)	Mouse	Human Cells
	ST2, also called IL-1 R4, is an Interleukin-1 receptor family glycoprotein that plays a role in Th2 immune responses. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiac myocytes....
TMPY-01710	IkB alpha/NFKBIA Protein, Human, Recombinant (His)	Human	E. coli
	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkB alpha, NFKBIA, or IKBA), is a member of the NF-kappa-B inhibitor family that function to inhibit the NF-kB transcription factor. NF...

RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli)

TMPJ-00662

Species: Human

Expression System: E. coli

Osteoprotegerin Protein, Human, Recombinant (aa 22-401, His)

TMPJ-01466

Species: Human

Expression System: Human Cells

ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His)

TMPJ-00850

Species: Mouse

Expression System: Human Cells

ST2/IL-1 RL1 Protein, Mouse, Recombinant (V192A, hFc)

TMPJ-00849

Species: Mouse

Expression System: Human Cells

IkB alpha/NFKBIA Protein, Human, Recombinant (His)

TMPY-01710

Species: Human

Expression System: E. coli

カタログ番号	製品名
L3800	NF-κB Signaling Compound Library		729 compounds
	A unique collection of 729 compounds targeting NF-κB signaling for high throughput screening and high content screening;

ライブラリー

NF-κB Signaling Compound Library

L3800

Compounds: 729